ABSTRACT
Objective Vaccination reduces the risk of acute COVID-19 in children, but it is less clear whether it protects against long COVID. We estimated vaccine effectiveness (VE) against long COVID in children aged 5 to 17 years. Methods This retrospective cohort study used data from 17 health systems in the RECOVER PCORnet electronic health record (EHR) Program for visits between vaccine availability, and October 29, 2022. Conditional logistic regression was used to estimate VE against long COVID with matching on age group (5 to 11, 12 to 17) and time period and adjustment for sex, ethnicity, health system, comorbidity burden, and pre-exposure health care utilization. We examined both probable (symptom-based) and diagnosed long COVID in the year following vaccination. Results The vaccination rate was 56% in the cohort of 1,037,936 children. The incidence of probably long COVID was 4.5% among patients with COVID-19, while diagnosed long COVID was 0.7%. Adjusted vaccine effectiveness within 12 months was 35.4% (95 CI 24.5 - 44.5) against probable long COVID and 41.7% (15.0- 60.0) against diagnosed long COVID. VE was higher for adolescents 50.3% [36.3 - 61.0]) than children aged 5-11 (23.8% [4.9 -39.0]). VE was higher at 6 months (61.4% [51.0 - 69.6]), but decreased to 10.6% (-26.8 - 37.0%) at 18 months. Discussion This large retrospective study shows a moderate protective effect of SARS-CoV-2 vaccination against long COVID. The effect is stronger in adolescents, who have higher risk of long COVID, and wanes over time. Understanding VE mechanism against long COVID requires more study, including EHR sources and prospective data. Discussion This large retrospective study shows a moderate protective effect of SARS-CoV-2 vaccination against long COVID. The effect is stronger in adolescents, who have higher risk of long COVID, and wanes over time. Understanding VE mechanism against long COVID requires more study, including EHR sources and prospective data.
Subject(s)
COVID-19ABSTRACT
Digital platforms have become valuable resources to citizens as they allow immediate access to quality information and news. Staying up to date with information and news is particularly vital in crises such as bushfires. The 2019–20 bushfire season in Australia was extreme, resulting in widespread devastation and loss of life, property and wildlife. Communicating with affected communities is a critical component of community response and resilience in a disaster. Organisations, such as ACT Emergency Services Agency and the NSW Rural Fire Service, need to provide timely, accurate and reliable information. This study investigated official communication using Facebook during the Orroral Valley bushfires from these two emergency services agencies and considers to what extent messaging demonstrated the characteristics of effective crisis communication, including application of the National Framework for Scaled Advice and Warnings to the Community. A content analysis of over 600 posts revealed marked differences in approaches. The study revealed the benefits of using a combination of text, images and infographics in communication activities. Suggestions are provided about how social media could be used more effectively by truly connecting with communities to improve community preparedness and resilience.